38473-30-2

Basic information

• Product Name: N-hydroxyphentermine
• Synonyms: N-hydroxyphentermine;N-Hydroxy-α,α-dimethylbenzeneethanamine;N-(2-methyl-1-phenylpropan-2-yl)hydroxylamine
• CAS NO: 38473-30-2
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.234
• Mol File: 38473-30-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 284.4°C at 760 mmHg
• Flash Point: 112.1°C
• Appearance: /
• Density: 1.022g/cm³
• Vapor Pressure: 0.0014mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: pKa 6.03(H2O,t = 25,I=1.0(KCl)) (Uncertain)
• CAS DataBase Reference: N-hydroxyphentermine(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxyphentermine(38473-30-2)
• EPA Substance Registry System: N-hydroxyphentermine(38473-30-2)

Safety Data

• Hazardous Substances Data: 38473-30-2(Hazardous Substances Data)

Usage

Uses

N-Hydroxyphentermine is a metabolite of Phentermine (P318830), a controlled substance (stimulant). Anorexic. An Amphetamine derivative.

InChI:InChI=1/C10H15NO/c1-10(2,11-12)8-9-6-4-3-5-7-9/h3-7,11-12H,8H2,1-2H3

Upstream product

• 34405-43-1 (2-methyl-2-nitropropyl)benzene 

Downstream Products

• 122-09-8 Phentermin 
• 52497-67-3 2-Benzyl-2-Nitrosopropan 

Relevant articles and documents

Electrochemical Reduction of Tertiary Nitroalkanes to Amines

Electrochemical reduction of tertiary nitroalkanes, 2-substituted-1,1-dimethyl-1-nitroethanes (1), was investigated in aqueous buffer solutions.In polarography, 1 with a phenyl group and/or a hydroxyl group at the 2-position showed an ill-defined wave in the weakly acidic and neutral pH region at relatively high negative potentials, in addition to a well-defined wave arising from the reduction of 1 to the corresponding hydroxylamine (2).Controlled potential electrolysis of 1 at the potential of the former wave gave the 1,1-dimethylethylamines (3) as well as the hydroxylamines 2.The amines 3 are formed exclusively from 2, probably via the O-protonated form.It is suggested that a phenyl group at the 2-position facilitates the reduction of 2 to 3 by enhancing the adsorption of 2 at the mercury cathode and that a hydroxyl group, while it interferes with the adsorption, assists the reduction by intramolecular hydrogen-bonding to stabilize the O-protonated form of 2.Keywords - tertiary nitroalkane; alkylhydroxylamine; electrochemical reduction; polarography; controlled potential electrolysis.