384793-16-2

Usage

Uses

Used in Agriculture:
(2-bromo-4-chloro-phenyl)-carbamic acid tert-butyl ester is used as a pesticide for controlling a wide range of pests, including insects and mites, on various crops. It works by inhibiting the activity of acetylcholinesterase, an enzyme that is essential for the proper functioning of the nervous system in insects, leading to paralysis and eventual death of the pests.
However, due to its toxic nature, (2-bromo-4-chloro-phenyl)-carbamic acid tert-butyl ester should be handled and used with caution, as it can have harmful effects on non-target organisms and the environment.

Upstream product

• 880384-41-8 N,N-di-tert-butyloxycarbonyl-2-bromo-4-chloroaniline 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 873-38-1 4-chloro-2-bromoaniline 

Downstream Products

• 719-64-2 5-chloro-3-phenylanthranil 
• 1440672-59-2 N-(2-bromo-4-chlorophenyl)-N-tert-butoxycarbonylphenylethynylamine 
• 1186637-27-3 N-(tert-butoxycarbonyl)-4-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1333120-11-8 tert-butyl (2-bromo-4-chlorophenyl)(2-methylallyl)carbamate 

Relevant academic research and scientific papers

Solvent-free, uncatalyzed asymmetric "ene" reactions of: N-Tert-butylsulfinyl-3,3,3-Trifluoroacetaldimines: A general approach to enantiomerically pure α-(trifluoromethyl)tryptamines

A novel approach to regioselectively substituted and stereoselectively α-Trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)-or (S)-Tert-butanesulfinyltrifluoroacetaldimine. B

Homogenous suspension of immunopotentiating compounds and uses thereof

The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: A route to functionalized indolines, isoquinolinones, and indoles

A general procedure for the palladium-catalyzed annulation of substituted haloanilines with norbornadiene gives functionalized indolines in 51-98% yield. These indolines can be rapidly converted to benzenoid- substituted indoles and tricyclic indolines. Extension to the use of substituted halobenzamides gives functionalized isoquinolinones in up to 86% yield.

COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.

An improved synthesis of N-Boc protected aryl amines

There are several known methods of protecting amines as their Boc derivatives. For less nucleophilic amines such as aryl amines these methods often give poor yields and are generally not satisfactory. Here, Boc aryl amines are obtained by first introducing two Boc groups followed by selective removal of one of them. This procedure works well for a number highly sterically hindered substrates as well as electron deficient and electron rich aryl amines.