3848-73-5

Basic information

• Product Name: 1-p-tolyl-4-trifluoroacetyl-piperazine
• Synonyms: 1-p-tolyl-4-trifluoroacetyl-piperazine
• CAS NO: 3848-73-5
• Molecular Weight: 272.27
• Mol File: 3848-73-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-p-tolyl-4-trifluoroacetyl-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-p-tolyl-4-trifluoroacetyl-piperazine(3848-73-5)
• EPA Substance Registry System: 1-p-tolyl-4-trifluoroacetyl-piperazine(3848-73-5)

Safety Data

• Hazardous Substances Data: 3848-73-5(Hazardous Substances Data)

Upstream product

• 39593-08-3 (4-methylphenyl)piperazine 
• 407-25-0 trifluoroacetic anhydride 
• 111185-41-2 1-(2,5-dihydro-1H-pyrrol-1-yl)-2,2,2-trifluoroethanone 
• 106-49-0 p-toluidine 

Downstream Products

• 39593-08-3 (4-methylphenyl)piperazine 

Relevant articles and documents

Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation

Ozonized 1-trifluoroacetyl-3-pyrroline (2a) and 3-sulfolene (6) were reduced with sodium cyanoborohydride (1) to afford the dialdehyde, which reacted in situ with the primary amines 3ad in the presence of 1 to give the piperazines 4ad (2160 percent) and the dioxothiomorpholines 7ad (2676 percent).Reduction of 7a and 7c with diisobutylaluminum hydride yielded the thiomorpholines 8a and 8c, respectively.On the other hand, the 9-membered azacrown ethers 10 and 11 were obtained when N,N'-dibenzylethylenediamine (9) was employed.The dioxothiomorpholine derivatives 13 of amino acids were also prepared by the same treatment.