38482-76-7 Usage
Uses
Used in Pharmaceutical Industry:
Biochanin A-7-O-β-D-glucuronide is used as a research compound for its potential anticancer properties. It is being studied for its ability to inhibit cancer cell proliferation, promote differentiation, and provide chemopreventive effects. The metabolite's role in the toxic properties of drugs containing carboxylic acid moieties is also a focus of investigation, aiming to improve drug safety and efficacy.
Used in Toxicology Research:
In the field of toxicology, Biochanin A-7-O-β-D-glucuronide is utilized as a subject of study to understand the biologic and toxicologic effects of acyl glucuronide metabolites. This research is crucial for the development of safer and more effective drugs, as well as for the identification of potential drug interactions and side effects.
Used in Drug Development:
Biochanin A-7-O-β-D-glucuronide may be employed as a lead compound in the development of new anticancer drugs. Its unique structure and potential biological activities make it a promising candidate for further research and optimization, with the goal of creating more effective and targeted cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 38482-76-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,4,8 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 38482-76:
(7*3)+(6*8)+(5*4)+(4*8)+(3*2)+(2*7)+(1*6)=147
147 % 10 = 7
So 38482-76-7 is a valid CAS Registry Number.
38482-76-7Relevant academic research and scientific papers
Yue, Tian,Chen, Ridao,Chen, Dawei,Liu, Jimei,Xie, Kebo,Dai, Jungui
, p. 6275 - 6284 (2019)
Many O-glucuronides exhibiting various pharmacological activities have been found in nature and in drug metabolism. The glucuronidation of bioactive natural products or drugs to generate glucuronides with better activity and druggability is important in drug discovery and research. In this study, by using two uridine diphosphate (UDP)-dependent glucuronosyltransferases (GATs, UGT88D4 and UGT88D7) from plants, we developed two glucuronidation approaches, pure enzyme catalysis in vitro and recombinant whole-cell catalysis in vivo, to efficiently synthesize bioactive O-glucuronides by the glucuronidation of natural products. In total, 14 O-glucuronides with different structures, including flavonoids, anthraquinones, coumarins, and lignans, were obtained, 7 of which were new compounds. Furthermore, one of the biosynthesized O-glucuronides, kaempferol-7-O-β-d-glucuronide (3a), potently inhibited protein tyrosine phosphatase (PTP) 1B with an IC50 value of 8.02 × 10-6 M. Some of the biosynthesized O-glucuronides also exhibited significant antioxidant activities.
