384832-34-2

Upstream product

• 384832-33-1 4-(4-Cyano-3-methylbenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 73831-13-7 4-cyano-3-methylbenzoic acid 

Downstream Products

• 500013-33-2 4-(4-(4-(tert-butyloxycarbonyl)piperazine-1-carbonylaminomethyl)-3-methylbenzoyl)-5,6,7,8-tetrahydrothieno[3,2-b]azepine 
• 384832-35-3 4-(3-Methyl-4-[3-(2,3,5,6-tetrafluorophenyl)ureidomethyl]benzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 384832-32-0 4-(4-[3-(2,6-Difluorophenyl)ureidomethyl]-3-methylbenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 

Relevant academic research and scientific papers

Non-peptide oxytocin agonists

The first non-peptide, low molecular weight agonists of the hormone oxytocin (OT) are reported. The most potent compound, 39, showed an EC 50 = 33 nM and was selective for the OT receptor. A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).

benzamide derivatives as oxytocin agonists and vasopressin antagonists

Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or Via receptor antagonists. Pharmaceutical compositions comprising such compounds are useful in the treatment of, inter alia, primary dysmenorrhoea.