384836-85-5Relevant academic research and scientific papers
Synthesis of amino-substituted indanes and tetralins via consecutive multibond-forming tandem processes
Grafton, Mark W.,Farrugia, Louis J.,Sutherland, Andrew
, p. 7199 - 7207 (2013/08/23)
A rapid and general approach for the synthesis of amino-substituted indanes and tetralins from readily available alkyne-derived allylic alcohols via consecutive multibond-forming tandem processes has been developed. In the first one-pot tandem process, a series of cyclic dienes were prepared using an Overman rearrangement under thermal conditions, followed by a ruthenium(II)-catalyzed ring closing enyne metathesis reaction. The resulting exo-dienes were then subjected to a second one-pot tandem process involving a highly regioselective Diels-Alder reaction with alkynes, quinones or nitriles and a subsequent oxidation step to give a diverse library of C-1 amino-substituted indanes and tetralins in good overall yields.
Scope and limitation of intramolecular Pauson-Khand reaction of fluorine-containing enynes
Ishizaki,Suzuki,Hoshino
, p. 81 - 90 (2007/10/03)
Intramolecular Pauson-Khand reaction of various fluorine-containing enynes was investigated under various conditions. The reaction of the substrates, which have fluorine atom(s) or fluorine-containing group(s) attached to alkenyl moiety, gave the corresponding cyclopentenones in low to moderate yield, while that of the substrates bearing fluorine-containing groups attached to alkynyl moiety afforded the corresponding cyclopentenones in low to high yield.
