38485-01-7

Usage

InChI:InChI=1/C12H15NO4.ClH/c1-16-9-5-7-3-4-13-11(12(14)15)8(7)6-10(9)17-2;/h5-6,11,13H,3-4H2,1-2H3,(H,14,15);1H

Upstream product

• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 1370371-82-6 N-(2,2-dimethoxyethyl)-α-(3,4-dimethoxyphenyl)glycine 
• 1370371-81-5 N-(2,2-dimethoxyethyl)-N-benzyl-α-(3,4-dimethoxyphenyl)glycine 
• 1370371-80-4 N-(2,2-diethoxyethyl)-α-(3,4-dimethoxyphenyl)glycine 
• 1244737-58-3 2-benzyloxycarbonyl-6,7-dimethoxy-1-tert-butylcarbamoyl-1,2,3,4-tetrahydroisoquinoline 
• 1244737-56-1 2-benzyloxycarbonyl-1-cyclohexylcarbamoyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1244737-79-8 N-cyclohexyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide 

Downstream Products

• 486-99-7 (6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolyl)methanol 

Relevant academic research and scientific papers

A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz-Fritsch-Bobbitt cyclization sequence

A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz-Fritsch-Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts.

Convenient synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid derivatives via isocyanide-based, three-component reactions

The three-component reactions of 3,4-dihydroisoquinolines, isocyanides, and benzyl chloroformate furnished 2-benzyloxycarbonyl-1,2,3,4- tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Hydrogenolysis or selective hydrolysis of the benzylo