38489-77-9

Upstream product

• 531-59-9 7-methoxycoumarin 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 1530-45-6 (carbethoxymethyl)triphenylphosphonium bromide 
• 85364-69-8 3-methyl-4-nitro-5-<2-(2-hydroxy-4-methoxyphenyl)ethenyl>isoxazole 
• 139386-27-9 ethyl 3-(2-hydroxy-4-methoxyphenyl)-(E)-2-propenoate 
• 141-82-2 malonic acid 

Downstream Products

• 531-59-9 7-methoxycoumarin 
• 93198-68-6 (E)-methyl 2’-hydroxy-4’-methoxycinnamate 
• 882653-43-2 4-methoxy-2-ethoxy-trans-cinnamic acid 
• 139386-27-9 ethyl 3-(2-hydroxy-4-methoxyphenyl)-(E)-2-propenoate 
• 66417-42-3 (E)-3-(2,4-dimethoxy-phenyl)-acrylic acid methyl ester 
• 1415264-78-6 (E)-3-(4-methoxy-2-((3,5,6-trimethylpyrazine-2-carbonyl)oxy)phenyl)acrylic acid 
• 1519726-64-7 6-methoxy-2-[(4-methylphenyl)sulfonyl]benzofuran 
• 882653-45-4 4-methoxy-2-ethoxy-cis-cinnamic acid 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel trimethylpyrazine-2- carbonyloxy-cinnamic acids as potent cardiovascular agents

A series of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids and esters were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro and also assayed for their protective effect against hydrogen peroxide (H 2O2)-induced oxidative damage on Ea.hy926 cells. The results showed that many compounds exhibited high activity in one or both of the assays, of which, compound F′10 displayed the highest protective effect on the proliferation of the damaged Ea.hy926 cells (EC50 = 1.7 μM), presenting almost 40 times higher potency than that of lipoic acid, and compound F3 was the most active anti-platelet aggregation agent with IC 50 = 9.6 μM, comparable to that of clopidogrel. The structure-activity relationships of these compounds were also discussed.

Base generator

A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic su

Enzyme-catalyzed conversion of chemical structures on the surface of gold nanorods

For developing metal nanoparticles of which surface chemical structures could be altered by enzymes in the cells, functional linkers caged by coumaric acids have been synthesized. Synthesized gold nanorod (GNR) conjugates possessing coumaric acid precursors underwent (porcine liver) esterase-catalyzed hydrolysis on their surface to afford GNRs coated with amino-functionalized polyethylene glycol and fluorescent coumarins as reporter molecules for monitoring the conversion. The chemical structural conversion on the GNR surfaces was successfully observed inside cells by fluorescence microscopy when GNR conjugates were incubated with tumor cells.

BASE GENERATOR, PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING MATERIAL COMPRISING THE PHOTOSENSITIVE RESIN COMPOSITION, AND PATTERN FORMING METHOD AND ARTICLE USING THE PHOTOSENSITIVE RESIN COMPOSITION

A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic su

PHASE TRANSFER CATALYSED WITTIG-HORNER SYNTHESIS PREPARATION OF HYDROXYCINNAMIC ESTERS FROM ORTHO HYDROXY AROMATIC ALDEHYDES OBTENTION OF HYDROXYCINNAMIC ACIDS

Reaction between (carbethoxymethyl)-triphenylphosphonium bromide and ortho hydroxyaromatic aldehydes gives hydroxycinnamic esters in a liquid-solid two phases system (potassium carbonate-methanol) with a good yield.

THE PREPARATION OF COUMARIC ACIDS VIA STYRYLISOXAZOLES

The preparation of coumaric acids (2a-f) by hydrolysis of the requisite 3-methyl-4-nitro-5-styrylisoxazoles (1a-f) is reported.