3849-19-2Relevant academic research and scientific papers
Novel heterocycles via 2-cyano-N-arylacetamide synthesis with docking studies of novel heterocycles as antimicrobial agents utilizing 2-cyano-N-arylacetamide
Abd El Salam, Hayam A.,Ewies, Ewies F.
, p. 1075 - 1085 (2020/04/17)
2-CYANO-N-arylacetamide reagent is used in a straight forward synthesis of various interesting nitrogenous heterocycles such as iminocoumarine, thiazole, dihydropyridine and imidazole or benzoimidazole. Molecular docking studies are described to show the most active compounds as antimicrobial agents. Also, Biological testing of these compounds for their antimicrobial activities against some strains of Gram bacteria and strains of fungi has been carried out.
Mild Synthesis of Substituted 1,2,5-Oxadiazoles Using 1,1′-Carbonyldiimidazole as a Dehydrating Agent
Neel, Andrew J.,Zhao, Ralph
supporting information, p. 2024 - 2027 (2018/04/16)
1,1′-Carbonyldiimidazole was found to induce the formation of a variety of 3,4-disubstituted 1,2,5-oxadiazoles (furazans) from the corresponding bisoximes at ambient temperature. This method enables these inherently energetic compounds to be prepared at t
Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation
Kobayashi, Yusuke,Kuroda, Mami,Toba, Natsuki,Okada, Mari,Tanaka, Rie,Kimachi, Tetsutaro
supporting information; experimental part, p. 6280 - 6283 (2012/01/06)
An efficient method for constructing quinoxalinone-N-oxides from cyanoacetanilides has been developed. This transformation can be achieved using inexpensive reagents and molecular oxygen under mild conditions, thus offering a practical pathway to quinoxalinone-containing pharmaceuticals such as ataquimast and opaviraline.
Heterocyclization of compounds containing diazo and cyano groups. 6. Theoretical and experimental investigations of cyclization of 2-cyano-2-diazoacetamides to 5-hydroxy-1,2,3-triazole-4-carbonitriles
Morzherin,Kolobov,Mokrushin,Brauer,Anders,Bakulev
, p. 22 - 36 (2007/10/03)
A series of N-alkyl- and N-aryl-2-cyano-2-diazoacetamides was synthesized by the reaction of 2-amino-2-cyanoacetamides with sodium nitrite in hydrochloric acid. The mechanism of their heteroelectrocyclization to 5-hydroxy-1,2,3-triazoles was investigated
