38490-36-7Relevant academic research and scientific papers
Improved addition of phenyllithium to hindered ketones by the use of non-polar media
Lecomte, Vincent,Stéphan, Elie,Jaouen, Gérard
, p. 3463 - 3465 (2002)
The use of a non-polar medium at room temperature is an efficient, cheap and easy way to improve the low reactivity of six hindered ketones towards phenyllithium.
Improved addition of organolithium reagents to hindered and/or enolisable ketones
Lecomte, Vincent,Stéphan, Elie,Le Bideau, Franck,Jaouen, Gérard
, p. 2169 - 2176 (2007/10/03)
A study of the addition of some aryl- and alkyllithium derivatives to some hindered and/or enolisable ketones in different solvents (polar and apolar) and, in some cases, at different temperatures and reaction times, will be presented here. The reversibility of the addition of aryllithium to these specific ketones will be observed and discussed. This approach is then used to prepare new steroids as precursor for potentially interesting substituted testosterones.
