38500-84-4Relevant academic research and scientific papers
Novel Reaction of Uracil Derivatives Possessing Electron-withdrawing Groups at the 5-Position with Amines: Exchange Reaction between the N1-Portion of Uracils and Amines
Hirota, Kosaku,Kitade, Yukio,Sajiki, Hironao,Maki, Yoshifumi,Yogo, Motoi
, p. 367 - 373 (2007/10/02)
The reaction of 1,3-disubstituted uracils possessing an electron-withdrawing group such as nitro, carbamoyl, and cyano at 5-position with primary amines resulted in the exchange of the N1-portion of the uracil ring with the amine moiety.The exchange reactions were influenced by the nature of substituents at the 5- and N1-position.The reaction sequence is explained in terms of addition, ring-opening, and ring-closure.
