38524-15-1

Upstream product

• 38523-95-4 3-Chloro-2-(4-methoxy-benzoylamino)-propionic acid methyl ester 
• 52778-77-5 3-Hydroxy-2-(4-methoxy-benzoylamino)-propionic acid methyl ester 
• 38518-38-6 N-(4-methylbenzoyl)-L-serine methyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 86109-34-4 methyl 3-(4'-methoxyphenyl)-2-methyl-3-oxopropanoate 

Downstream Products

• 1084941-13-8 Bz(4-OMe)-ΔAla(β,β-I)-OMe 
• 1242682-51-4 Bz(4-OMe)-ΔAla(β,β-Br)-OMe 

Relevant academic research and scientific papers

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds provides a simple and atom-economical approach toward enamides and isoquinolones. This paper reports two catalyst systems for these transformations which employ iron(ii) complexes [Fe(dpbz)]Br2 (dpbz = 1,2-bis(diphenylphosphino)benzene) and FeBr2/Et3N, respectively. [Fe(dpbz)]Br2 was found to be highly effective at converting 2-azido-2,3-dihydro-1H-inden-1-ones to isoquinolones. The reagent combination of FeBr2/Et3N, on the other hand, exhibited a broader catalytic scope, owing to the beneficial effect of Et3N. This latter catalyst system enables 2-azido-2-methyl-1,3-dicarbonyl compounds to be converted to the corresponding enamides under mild conditions in good yields.

Synthesis of substituted oxazoles from N-acyl-β-hydroxyamino acid derivatives

Several N-acyl-β-hydroxyamino acids were prepared and treated with di-tert-butyl dicarbonate in the presence of 4-(dimethylamino)pyridine, followed by treatment with N,N,N′,N′-tetramethylguanidine to give the corresponding N-acyldehydroamino acids in good