38528-41-5Relevant academic research and scientific papers
Anticancer Activity of 2-Amino-substituted-1,4-naphthoquinone Derivatives in Ovarian Cancer Cells
Shin, Sujeong,Lee, Haneul,Jeon, Cheolmin,Preya, Umma Hafsa,Choi, Jung-Hye,Park, Jeong Ho
, p. 1411 - 1414 (2017)
2-Amino-substituted-1,4-naphthoquinone derivatives (10–17) were synthesized from coupling reaction between 1,4-dihydroxynaphthalene and amines in the presence of catalyst CeCl3.7H2O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC50 10 μM) on all three ovarian cancer cells.
Novel 2-amine substituted 1,4-naphthoquinone compounds and pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient
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Paragraph 0154-0157, (2018/04/21)
The present invention relates to a novel 2-amine substituted 1,4-naphthoquinone compound in which various amine groups are substituted at the 2-position of 1,4-naphthoquinone, and a pharmaceutical composition for preventing or treating cancer comprising the same. The 2-amine substituted 1,4-naphthoquinone compound of the present invention exhibits low cytotoxicity and exhibits excellent inhibitory activity against cancer cells, particularly colon cancer or ovarian cancer cells, and thus can be effectively used for prevention or treatment of cancer.COPYRIGHT KIPO 2018
Synthesis and screening of substituted 1,4-naphthoquinones (NPQs) as antifilarial agents
Mathew, Nisha,Karunan, Twinkle,Srinivasan, Lakshmy,Muthuswamy, Kalyanasundaram
experimental part, p. 188 - 196 (2011/10/30)
Eleven amino-substituted 1,4-naphthoquinones were synthesized via the reaction of 1,4-naphthoquinone with different primary and secondary mono- and diamines in the presence of dichloromethane ethanol (1:2) solvent at room temperature. All compounds were p
