38530-07-3

Basic information

• Product Name: 6-(2-furyl)pyridazin-3(2H)-one
• Synonyms: 6-(2-furyl)pyridazin-3(2H)-one;3(2H)-pyridazinone, 6-(2-furanyl)-;6-(2-furyl)-3(2H)-pyridazinone(SALTDATA: FREE);6-(2-furyl)-2H-pyridazin-3-one;6-furan-2-yl-2H-pyridazin-3-one;6-(Furan-2-yl)-2,3-dihydropyridazin-3-one
• CAS NO: 38530-07-3
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.14544
• Mol File: 38530-07-3.mol

Chemical Properties

• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.87±0.40(Predicted)
• CAS DataBase Reference: 6-(2-furyl)pyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-furyl)pyridazin-3(2H)-one(38530-07-3)
• EPA Substance Registry System: 6-(2-furyl)pyridazin-3(2H)-one(38530-07-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 38530-07-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-(2-furyl)pyridazin-3(2H)-one is used as a building block for the synthesis of pharmaceutical drugs due to its potential biological and pharmacological activities. Its unique structure allows for the development of new drug candidates with specific therapeutic properties.
Used in Material Science:
6-(2-furyl)pyridazin-3(2H)-one is used in the development of new materials, leveraging its chemical properties and potential interactions with other compounds. Its application in material science can lead to the creation of innovative materials with unique properties for various industries.
Used in Organic Synthesis:
6-(2-furyl)pyridazin-3(2H)-one serves as a reagent in organic synthesis, facilitating the formation of complex organic molecules. Its presence in reactions can enhance the synthesis process, leading to the production of desired compounds with improved efficiency and selectivity.

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 298-12-4 Glyoxilic acid 

Relevant articles and documents

Endothelin receptor antagonists

This invention relates to pyridizinone derivatives of formula I STR1 wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.