385442-68-2

Basic information

• Product Name: 2'-(4-formyl)benzoyl cephalomannine
• Synonyms: 2'-(4-formyl)benzoyl cephalomannine
• CAS NO: 385442-68-2
• Molecular Weight: 964.033
• Mol File: 385442-68-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-(4-formyl)benzoyl cephalomannine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(4-formyl)benzoyl cephalomannine(385442-68-2)
• EPA Substance Registry System: 2'-(4-formyl)benzoyl cephalomannine(385442-68-2)

Safety Data

• Hazardous Substances Data: 385442-68-2(Hazardous Substances Data)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 71610-00-9 cephalomannine 

Relevant articles and documents

Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents

Five compounds composed of a taxoid (paclitaxel or cephalomannine) and a 4′-O-demethyl epipodophyllotoxin derivative joined by an imine linkage were prepared and evaluated as cytotoxic agents and inhibitors of mammalian DNA topoisomerase II. Compounds 12 and 14-16 exhibited comparable or better activity than the unconjugated epipodophyllotoxin derivatives in most tumor cell lines, and 12, 15, and 16 also showed enhanced activity against paclitaxel-resistant cells. Compound 13, which contains an epipodophyllotoxin moiety at both the taxoid 2′ and 7 positions, did not stimulate protein-DNA breaks, but was 2-fold more potent than 12 and 15 and comparable to GL-331 in the topo II inhibitory assay.