38552-84-0Relevant academic research and scientific papers
Enantioselective Cu-catalyzed 1,4-addition of Grignard reagents to cyclohexenone using Taddol-derived phosphine-phosphite ligands and 2-methyl-THF as a solvent
Robert, Tobias,Velder, Janna,Schmalz, Hans-Guenther
supporting information; experimental part, p. 7718 - 7721 (2009/04/10)
A small library of modular P,P ligands was screened and a potent Cu-based catalyst system was identified for highly enantioselective 1,4-additions to cyclohexenone with an unprecedented broad spectrum of Grignard reagents. Surprisingly, the highest selectivities were achieved in most cases in 2-methyl-THF, a green solvent underestimated so far.
