385785-18-2

Upstream product

• 110295-93-7 (2-amino-thiazol-5-yl)acetic acid methyl ester 
• 76-83-5 trityl chloride 
• 385785-17-1 methyl [2-(tritylamino)-1,3-thiazol-5-yl]acetate 

Downstream Products

• 385785-32-0 N-(3-fluorophenyl)-2-[2-(tritylamino)-1,3-thiazol-5-yl]acetamide 
• 723278-14-6 di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate 
• 385782-89-8 N-(3-fluorophenyl)-2-{2-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide 
• 385782-93-4 N-(3-fluorophenyl)-2-{2-[(7-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide 
• 723279-41-2 N-(3-fluorophenyl)-2-{2-[(7-{3-[(2-hydroxyethyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide 
• 723281-45-6 2-(2-amino-1,3-thiazol-5-yl)-N-(2,3-difluorophenyl)acetamide-7-(3-chloropropoxy)-6-methoxyquinazoline 
• 723278-29-3 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide 
• 723282-92-6 N-(3-fluorophenyl)-2-(2-(7-(2-chloroethoxy)-6-methoxyquinazolin-4-yl-amino)-1,3-thiazol-5-yl)acetamide 
• 878376-01-3 2-(2-amino-1,3-thiazol-5-yl)-N-(2,3-difluorophenyl)acetamide 
• 385785-31-9 2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide 
• 723281-43-4 N-(2,3-difluorophenyl)-2-[2-(tritylamino)-1,3-thiazol-5-yl]acetamide 

Relevant academic research and scientific papers

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors

The synthesis of a novel series of quinazolines substituted at C4 by five-membered ring aminoheterocycles is reported. Their in vitro structure-activity relationships versus Aurora A and B serine-threonine kinases is discussed. Our results demonstrate tha

QUINAZOLINE COMPOUNDS

Quinazoline derivatives of formula (I) wherein A is 5-membered heteroaryl containing a sulphur atom and optionally containing one or more nitrogen atoms; compositions containing them, processes for their preparation and their use in therapy.