3858-83-1

Basic information

• Product Name: p-aminobenzamidine
• Synonyms: 4-Aminobenzenecarbamidine;ABD;4-aMinobenziMidaMide;NSC 227928;4-aminobenzene-1-carboximidamide
• CAS NO: 3858-83-1
• Molecular Formula: C₇H₉N₃
• Molecular Weight: 135.19
• EINECS: 223-370-7
• Mol File: 3858-83-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 182 °C
• Boiling Point: 238.87°C (rough estimate)
• Flash Point: 129°C
• Appearance: /
• Density: 1.1423 (rough estimate)
• Refractive Index: 1.5400 (estimate)
• PKA: 13.35±0.50(Predicted)
• CAS DataBase Reference: p-aminobenzamidine(CAS DataBase Reference)
• NIST Chemistry Reference: p-aminobenzamidine(3858-83-1)
• EPA Substance Registry System: p-aminobenzamidine(3858-83-1)

Safety Data

• Hazardous Substances Data: 3858-83-1(Hazardous Substances Data)

Usage

General Description

p-Aminobenzamidine, also known as 4-Aminobenzamidine or 4-ABZ, is a chemical compound primarily used in medical research and development. It is a potent and specific inhibitor of trypsin-like serine proteases and is often applied in studies involving blood coagulation, fibrinolysis, and kinin generation. It also plays a significant role in the inhibition of enzymes to prevent protease degradation. Often it is used in the creation of irreversible enzyme inhibitors by acting as a scaffolding for other chemical groups. p-aminobenzamidine is relatively stable, although it should be stored in a cool and dry place for optimal preservation.

InChI:InChI=1/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 619-72-7 4-nitrobenzonitrile 
• 277319-62-7 4-amino-N'-hydroxybenzimidamide 
• 1610930-44-3 p-amino-N,N'-dihydroxybenzamidine 
• 1610930-41-0 p-amino-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine 
• 1610930-38-5 p-nitro-O,O'-bis(tert-butyldimethylsilyl)-N,N'-dihydroxybenzamidine 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 
• 25412-75-3 4-nitrobenzamidine 
• 15723-90-7 4-nitrobenzamidine hydrochloride 

Downstream Products

• 147291-56-3 tert-butyl [(4-aminophenyl)(imino)methyl]carbamate 

Relevant articles and documents

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Method for synthesizing benzamidine derivative

The invention discloses a method for synthesizing a benzamidine derivative. According to the method, a reaction for preparing the benzamidine derivative from a benzonitrile raw material can be efficiently and greenly completed by use of an ionic-liquid-loaded metal nano catalyst, and the ionic-liquid-loaded metal nano catalyst has the advantages of being high in activity and recoverable. Benzamidine can be obtained by reaction of benzonitrile and hydroxylamine hydrochloride to obtainbenzamidoxime and hydrogenation reduction of the benzamidoxime in the presence of the ionic-liquid-loaded metal nano catalyst for catalysis.

Synthesis method for benzamidine derivatives

The invention discloses a synthesis method for benzamidine derivatives. According to the synthesis method disclosed by the invention, a reaction of preparing benzamidine derivatives from benzonitrile raw materials is completed in a green and efficient manner by using an ionic liquid-supported nano-metal catalyst, and the catalyst is high in activity and recoverable. Benzamidoxime is formed from benzonitrile and hydroxylamine hydrochloride, and then benzamidine is obtained through hydrogenation reduction under the catalysis of the ionic liquid-supported nano-metal catalyst.