38584-59-7

Usage

Uses

Used in Pharmaceutical Research:
Methyl 3-((2-nitrophenyl)amino)propanoate is used as an intermediate in pharmaceutical research for the development of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of new drug candidates.
Used in Dye Production:
In the dye industry, methyl 3-((2-nitrophenyl)amino)propanoate is used as an intermediate for the production of various dyes. Its chemical properties make it suitable for creating a range of colors and hues in different applications.
Safety Precautions:
It is important to handle methyl 3-((2-nitrophenyl)amino)propanoate with care as it may be harmful if ingested or inhaled, and it can cause skin and eye irritation upon contact. Additionally, it should be stored in a cool, dry place away from heat and open flames to prevent any potential hazards.

Upstream product

• 88-74-4 2-nitro-aniline 
• 292638-85-8 acrylic acid methyl ester 
• 3196-73-4 methyl 3-aminopropanoate hydrochloride 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 1270914-58-3 methyl 3-((2-aminophenyl)amino)propanoate 

Relevant academic research and scientific papers

Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains

Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of therapeutic relevance to cancer and inflammatory disease, respectively. Herein we report substituted benzo[b]isoxazolo[4,5-d]azepines and benzotriazolo[4,3-d][1,4]diazepines as fragment-derived novel inhibitors of the bromodomain of BRD4. Compounds from these series were potent and selective in cells, and subsequent optimization of microsomal stability yielded representatives that demonstrated dose- and time-dependent reduction of plasma IL-6 in mice.

BROMODOMAIN INHIBITORS AND USES THEREOF

The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Fast, easy, solvent-free, microwave-promoted Michael addition of anilines to α,β-unsaturated alkenes: synthesis of N-aryl functionalized β-amino esters and acids

The rapid, simple, microwave-promoted synthesis of N-aryl functionalized β-amino esters using Michael addition reactions is presented. Reactions are performed neat at 200 °C for 20 min and are catalyzed by acetic acid. The esters can be easily hydrolyzed to the corresponding N-aryl functionalized β-amino acids.