385841-97-4Relevant articles and documents
AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey
Selliah, Robert D.,Hellberg, Mark R.,Sharif, Najam A.,McLaughlin, Marsha A.,Williams, Gary W.,Scott, Daniel A.,Earnest, David,Haggard, Karen S.,Dennis Dean,Delgado, Pete,Gaines, Michael S.,Conrow, Raymond E.,Klimko, Peter G.
, p. 4525 - 4528 (2004)
A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug of the