386254-60-0Relevant academic research and scientific papers
Synthesis, characterisation and biological studies of mixed-ligand nickel (II) complexes containing imidazole derivatives and thiosemicarbazide Schiff bases
Ishak, Nurul N.M.,Jamsari, Junita,Ismail,Tahir, Mohamed I.M.,Tiekink, Edward R.T.,Veerakumarasivam, Abhi,Ravoof, Thahira B.S.A.
, (2019)
Four new mixed-ligand Ni(II) complexes (1–4) containing imidazole (im) or benzimidazole (bz) and tridentate Schiff bases derived from 2,4-dihydroxybenzaldehyde (24D) and 4-methyl-3-thiosemicarbazide (MT24D) or 4-phenyl-3-thiosemicarbazide (PT24D) were syn
Preparation and characterization of rhenium(I) complexes with thiosemicarbazone ligands derived from resorcinol
Nú?ez-Montenegro, Ara,Carballo, Rosa,Abram, Ulrich,Vázquez-López, Ezequiel M.
, p. 221 - 228 (2013)
New neutral tricarbonylrhenium(I) complexes with bidentate thiosemicarbazone ligands derived from resorcinol have been prepared. Ligands were obtained by condensation reactions of 2,4-dihydroxybenzaldehyde (dhb) and 2,4-dihydroxyacetophenone (dha) with th
Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase i
Tan, Kong Wai,Seng, Hoi Ling,Lim, Fei Shen,Cheah, Shiau-Chuen,Ng, Chew Hee,Koo, Kong Soo,Mustafa, Mohd. Rais,Ng, Seik Weng,Maah, Mohd. Jamil
, p. 275 - 284 (2012)
Four thiosemicarbazones ligands, H3T(1), H3M(2), H3E(3) and H3P(4) have been prepared with good yield by refluxing 2,4-dihydroxybenzaldehyde with N(4)-substituted thiosemicarbazide in ethanol (H3T(1) = 2,4-dihydroxybenzaldehyde thiosemicarbazone; H 3M(2) = 2,4-dihydroxybenzaldehyde 4-methylthiosemicarbazone; H 3E(3) = 2,4-dihydroxybenzaldehyde 4-ethylthiosemicarbazone and H 3P(4) = 2,4-dihydroxybenzaldehyde 4-phenylthiosemicarbazone). Reactions of these ligands with zinc acetates in the presence of 2,2′-bipyridine lead to the formation of zinc(II) complexes of formulation [Zn(bpy)L](5-8) (bpy = 2,2′-bipyridine; L = doubly deprotonated thiosemicarbazones = HT(5); HM(6); HE(7) and HP(8)). These compounds were characterized and their cytotoxicity and topoisomerase I inhibition activities studied. X-ray diffraction study indicates that complex 8 is five coordinated and the coordination geometry around zinc(II) is trigonal bipyramidal distorted square based pyramid (TBDSBP). The doubly deprotonated thiosemicarbazone acts as a tridentate ONS-donor ligand while 2,2-bipyridne as the NN-donor ligand. Complexes 6, 7 and 8 are more cytotoxic towards PC3 (prostate cancer cell line) than RWPE-1 (prostate normal cell line). The cytotoxicity and topoisomerase I inhibition activities seem to be dependent on the N(4) substituent of the thiosemicarbazone moiety.
