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• 492-88-6 3-ethoxysalicylaldehyde 
• 5351-23-5 4-hydroxybenzoic acid hydrazide 

Relevant academic research and scientific papers

Biological evaluation of organometallic palladium(II) complexes containing 4-hydroxybenzoic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide: Synthesis, structure, DNA/protein binding, antioxidant activity and cytotoxicity

New palladium(II) complexes, [Pd(PPh3)L] (2) and [Pd(AsPh3)L] (3), were synthesized using 4-hydroxybenzoic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (1) ligand (H2L), and characterized using various physicochemical techniques. The molecular structures of 2 and 3 were determined using single-crystal X-ray diffraction, which reveals a square planar geometry around the palladium(II) metal ion. In vitro DNA binding studies were conducted using UV–visible absorption spectroscopy, emission spectroscopy, cyclic voltammetry and viscosity measurements, which suggest that the metal complexes act as efficient DNA binders. The interaction of ligand H2L and complexes 2 and 3 with bovine serum albumin (BSA) was investigated using UV–visible and fluorescence spectroscopies. Absorption and emission spectral studies indicate that complexes 2 and 3 interact with BSA protein more strongly than the parent ligand. The free radical scavenging potential of all the synthesised compounds (1–3) was also investigated under in vitro conditions. In addition, the in vitro cytotoxicity of the complexes to tumour cells lines (HeLa and MCF-7) was examined using the MTT assay method.

Synthesis and crystal structures of dioxomolybdenum(VI) complexes with similar benzohydrazone ligands

Two new dioxomolybdenum(VI) complexes, [MoO2L1(EtOH)] (1) and [MoO2L2(H2O)] (2), where L1 and L2 are the dianionic forms of N′-(3-ethoxy-2- hydroxybenzylidene)-4-hydroxybenzoh- ydrazide and N′-(3-ethoxy-2- hydroxybenzylidene)-2-methylbenz- ohydrazide, respectively, have been synthesized and characterized by elemental analysis, FT-IR spectra, and single-crystal X-ray determination. The crystal of (1) is triclinic: space group P-1, a = 7.806(2), b = 9.947(2), c = 12.225(3) A, α = 82.915(2), β = 89.845(2), γ = 78.063(2)°, V = 921.4(4) A3, Z = 2, R 1 = 0.0374, wR2 = 0.1041. The crystal of (2) is monoclinic: space group P21/c, a = 8.120(2), b = 25.848(2), c = 8.590(2) A, β = 95.247(2)°, V = 1795.3(6) A3, Z = 4, R 1 = 0.0473, wR2 = 0.0734. Mo atoms in the complexes are coordinated by phenolic O, imino N, and enolic O atoms of the benzohydrazone ligand, oxo O atoms, and solvate O atom, forming octahedral coordination. In the crystal structure of (1), adjacent two molecules are linked through intermolecular O-H···N hydrogen bonds, forming dimers. The dimers are further linked through intermolecular O-H···O hydrogen bonds, forming 1D chains. In the crystal structure of (2), adjacent two molecules are linked through intermolecular O-H···N and O-H···O hydrogen bonds, forming dimers. The complexes have effective catalytic properties for sulfoxidation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file. Copyright Taylor & Francis Group, LLC.