3863-59-0 Usage
Uses
Used in Pharmaceutical Industry:
Hydrocortisone phosphate is used as a glucocorticoid for its anti-inflammatory and immunosuppressive properties. It is employed in the treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, lupus, and asthma. Its ability to suppress the immune system makes it a valuable drug in the management of allergies and organ transplant rejection.
Used in Research Applications:
Hydrocortisone phosphate is used as a research tool in the study of ulcerative colitis (UC) and other inflammatory bowel diseases. Its inhibitory effects on IL-6 and IL-3 make it a valuable compound for investigating the underlying mechanisms of these conditions and for developing novel therapeutic strategies.
Used in Drug Formulation:
Hydrocortisone phosphate can be incorporated into various drug formulations, such as tablets, injections, and topical creams, to provide targeted anti-inflammatory and immunosuppressive effects. Its enhanced water solubility and bioavailability make it an attractive option for pharmaceutical development.
Originator
Corphos,Tilden Yates,US,1959
Manufacturing Process
21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile
(125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and
triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4
hours. The solvent was removed in vacuo and the residue, dissolved in
ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb
225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with
20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate
was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of
solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes.
The solid insoluble inorganic phosphate was filtered off and washed with
methanol (200 ml). The slightly cloudy filtrate was filtered again, and
evaporated to dryness in vacuo. The residual gum dissolved readily in water
(40 ml) and on addition of acetone (600 ml) to the solution a mixture of
sodium salts of hydrocortisone 21-phosphate separated as a white solid. This
was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2
hr to constant weight. Yield 4.45 g.
Therapeutic Function
Glucocorticoid
Check Digit Verification of cas no
The CAS Registry Mumber 3863-59-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,6 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3863-59:
(6*3)+(5*8)+(4*6)+(3*3)+(2*5)+(1*9)=110
110 % 10 = 0
So 3863-59-0 is a valid CAS Registry Number.
