38645-22-6Relevant academic research and scientific papers
Reactions des radicaux 6-hydroxy-5,6-dihydrothymid-5-yles en solution aqueuse
Berger, M.,Sarrazin, F.,Cadet, J.
, p. 853 - 862 (2007/10/02)
The main reactions of 6-hydroxy-5,6-dihydrothymid-5-yl radicals, specifically obtained by electron capture dissociation of the trans diastereomers of 5-bromo-6-hydroxy-5,6-dihydrothymidine, were determined in aqueous solutions on the basis of final product analysis.In oxygen-free aqueous solutions a complex mixture of both monomeric and dimeric decomposition products was produced.It is worth mentioning the radiation-induced formation of modified nucleosides which involves the transient generation of 5-(2'-deoxyuridyl)methyl radical.This may be explained in terms of initial formation of 6-hydroxy-5,6-dihydrothymid-5-yl radicals, followed by dehydration and subsequent deprotonation.
Independent Generation of the Major Adduct of Hydroxyl Radical and Thymidine. Examination of Intramolecular Hydrogen Atom Transfer in Competition With Thiol Trapping.
Barvian, Mark R.,Greenberg, Marc M.
, p. 6057 - 6060 (2007/10/02)
5,6-Dihydro-5-hydroxythymid-6-yl (1) has been generated from 2 via photoinduced electron transfer from N-methylcarbazole.In agreement with prior reports, deuterium incorporation in conjunction with (2)H NMR analysis of 5,6-dihydro-5-hydroxythymidine (3) f
Oxidation of Thymidine by Peroxymono- and Peroxodisulfate Ions
Itahara, Toshio,Koga, Sunao
, p. 85 - 88 (2007/10/02)
Oxidation of thymidine by KHSO5 gave thymidine glycols, while a similar treatment with Na2S2O8 gave 5-hydroxymethyl-2'-deoxyuridine.
Radiation-Induced Degradation of Purine and Pyrimidine 2'-Deoxyribonucleosides in Aqueous KBr Solutions
Cadet, J.,Voituriez, L.,Berger, M.,Myers, L. S., (Jr.)
, p. 1643 - 1651 (2007/10/02)
Steady-state γ-radiolysis of 5E-4 M pyrimidine and purine 2'-deoxyribonucleosides in aqueous solutions saturated with N2, N2O and O2, respectively, have been carried out in the presence of 0.1 M KBr.The main final degradation products have been isolated and characterised by various spectroscopic measurements including 1H and 13C NMR, UV, C.D. and mass spectrometry.The radiation-induced decomposition of thymidine is mostly accounted for by an ionic mechanism involving Br2, the decay product of Br2, as the reactive oxidising specie.On the other hand the degradation of the purine ring of 2'-deoxyadenosine and 2'-deoxyguanosine may be accounted for by the action of Br2 or Br3. - Keywords: 2'-Deoxyribonucleosides, Inorganic Radical, γ-Irradiation, Radical Reactions, Thymidine Oxidation
