38651-07-9

Basic information

• Product Name: 1,3-Dibromo-1-phenyl-2-butanone
• Synonyms: 1,3-Dibromo-1-phenyl-2-butanone
• CAS NO: 38651-07-9
• Molecular Weight: 0
• Mol File: 38651-07-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dibromo-1-phenyl-2-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dibromo-1-phenyl-2-butanone(38651-07-9)
• EPA Substance Registry System: 1,3-Dibromo-1-phenyl-2-butanone(38651-07-9)

Safety Data

• Hazardous Substances Data: 38651-07-9(Hazardous Substances Data)

Usage

Appearance

Yellow to brown crystalline solid

Solubility

Soluble in organic solvents

Uses

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of other organic compounds
c. Reagent in organic chemistry reactions
d. Formation of carbon-carbon bonds

Odor

Distinctive

Classification

Hazardous chemical

Handling

Should be handled with caution

Upstream product

• 1007-32-5 benzyl ethyl ketone 

Downstream Products

• 56764-03-5 2-(3-Bromo-phenyl)-3-methyl-cycloprop-2-enone 
• 26307-30-2 2-methyl-3-phenylcyclopropenone 

Relevant articles and documents

Organocatalytic Regiodivergent C?C Bond Cleavage of Cyclopropenones: A Highly Efficient Cascade Approach to Enantiopure Heterocyclic Frameworks

Here a highly efficient cascade approach is reported that combines a cycloaddition reaction with a regioselective strain-release process to afford diverse heterocyclic frameworks through bifunctional catalysis. The cooperation of hydrogen-bonding network activation and a regiodivergent strain-assisted effect is the key to promoting this complex chemical transformation, leading to the generation of two different ring systems in high yields with excellent stereoselectivities. The reaction proceeded by a mechanism involving a “spring-loaded” intermediate with switchable C?C bond cleavages achieved by controllable ring-strain release. This reaction was also amenable to gram scale synthesis with only 0.1 mol % catalyst loading.