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386704-12-7

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386704-12-7 Usage

General Description

6-(Trifluoromethyl)pyridine-3-carboxaldehyde is a chemical compound with the molecular formula C8H5F3NO. It is a yellow liquid with a distinct odor and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE is also used as a building block for the creation of various heterocyclic compounds, which are important in the development of active pharmaceutical ingredients. 6-(Trifluoromethyl)pyridine-3-carboxaldehyde is known for its strong and distinctive odor, and it should be handled with care due to its potential irritant and harmful effects if exposed to skin, eyes, or if inhaled. Additionally, it is important to dispose of this chemical properly to avoid environmental contamination and harm to human health.

Check Digit Verification of cas no

The CAS Registry Mumber 386704-12-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,6,7,0 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 386704-12:
(8*3)+(7*8)+(6*6)+(5*7)+(4*0)+(3*4)+(2*1)+(1*2)=167
167 % 10 = 7
So 386704-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F3NO/c8-7(9,10)6-2-1-5(4-12)3-11-6/h1-4H

386704-12-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • TCI America

  • (T2838)  6-(Trifluoromethyl)-3-pyridinecarboxaldehyde  >98.0%(GC)

  • 386704-12-7

  • 1g

  • 1,420.00CNY

  • Detail
  • TCI America

  • (T2838)  6-(Trifluoromethyl)-3-pyridinecarboxaldehyde  >98.0%(GC)

  • 386704-12-7

  • 5g

  • 4,890.00CNY

  • Detail
  • Alfa Aesar

  • (H64054)  2-(Trifluoromethyl)pyridine-5-carboxaldehyde, 95%   

  • 386704-12-7

  • 250mg

  • 196.0CNY

  • Detail
  • Alfa Aesar

  • (H64054)  2-(Trifluoromethyl)pyridine-5-carboxaldehyde, 95%   

  • 386704-12-7

  • 1g

  • 675.0CNY

  • Detail
  • Alfa Aesar

  • (H64054)  2-(Trifluoromethyl)pyridine-5-carboxaldehyde, 95%   

  • 386704-12-7

  • 5g

  • 2548.0CNY

  • Detail
  • Aldrich

  • (640085)  6-(Trifluoromethyl)pyridine-3-carboxaldehyde  95%

  • 386704-12-7

  • 640085-1G

  • 1,962.09CNY

  • Detail
  • Aldrich

  • (640085)  6-(Trifluoromethyl)pyridine-3-carboxaldehyde  95%

  • 386704-12-7

  • 640085-5G

  • 6,879.60CNY

  • Detail

386704-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(Trifluoromethyl)nicotinaldehyde

1.2 Other means of identification

Product number -
Other names 5-Formyl-2-(trifluoromethyl)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:386704-12-7 SDS

386704-12-7Relevant articles and documents

Microwave synthesis method of 6-trifluoromethylpyridylaldehyde

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Paragraph 0033-0038; 0043-0048, (2021/01/20)

The invention relates to a microwave synthesis method of 6-trifluoromethylpyridylaldehyde. According to the method, a reaction is performed in a reaction tank by using a microwave irradiation technique; 1 eq of 6-trifluoromethylpyridinemethanol is added, a solvent is added to dissolve 6-trifluoromethylpyridinemethanol, 0.01-0.1 eq of a catalyst and 1-1.5 eq of an oxidant are added, microwave powerand temperature are set to react after feeding is finished, after the reaction is finished, rotary evaporation and concentration is performed on the reaction solution to obtain a solid product, and finally the solid product is separated and purified to obtain the 6-trifluoromethylpyridylaldehyde. Compared with the prior art, the method provided by the invention has the advantages of short reaction time, mild conditions, few side reactions and high yield, simplifies the production process, reduces the production cost and cycle, is easy to realize the popularization of industrial production, and is especially suitable for large-scale production of an intermediate 6-trifluoromethyl nicotinaldehyde of a colony stimulating factor 1 receptor (CSF-1R) inhibitor.

Synthetic process of 6-(trifluoromethyl)pyridine-3-carboxaldehyde

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Paragraph 0011;, (2016/11/21)

The invention discloses a synthetic process of 6-(trifluoromethyl)pyridine-3-carboxaldehyde. The synthetic process comprises the following steps: under the protection of nitrogen, adding 1 eq of 2-trifluoromethyl-5-bromopyridine (calculated as the stoichiometric ratio) into a reaction vessel, dissolving with an organic solvent, controlling the temperature to be minus 20-10 DEG C, adding 1.0-5.0 eq of a stabilizer, dropwise adding 1.0-2.0 eq of a butyl lithium n-hexane solution while fully stirring, further adding 1.5-3.0 eq of dimethyl formamide, rising the temperature naturally, stirring overnight, and purifying the crude product by recrystallization. The synthetic process has the following positive effects: the activity of butyl lithium is partially reduced by adopting the stabilizer introducing method, the stability of the reaction at the intermediate state is improved, side reaction due to higher reaction temperature is inhibited, the reaction with dimethyl formamide is ensured, the yield is improved, problems in the prior art of high energy consumption and non-industrialization due to ultra-low temperature conditions are avoided at the same time, so that continuous production on general equipment can be achieved, the product quality is stable and reliable, and the purity can reach 98% or above.

Trifluoromethylation of (hetero)aryl iodides and bromides with copper(i) chlorodifluoroacetate complexes

Lin, Xiaoxi,Li, Zhengyu,Han, Xiaoyan,Weng, Zhiqiang

, p. 75465 - 75469 (2016/08/24)

A new copper-mediated trifluoromethylation reaction using copper(i) chlorodifluoroacetate complexes as reagents is reported. The complex [L2Cu][O2CCF2Cl] (L = bpy, dmbpy, phen) reacted with (hetero)aryl iodides and bromides in the presence of CsF in DMF at 75 °C to afford the trifluoromethylarenes in good to excellent yields. High compatibility with various chemical functions or (hetero)cycles was also observed in the reaction. A reaction mechanism involving a difluorocarbene intermediate, along with a subsequent formation of a -CF3 anion was proposed.

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