386706-05-4Relevant academic research and scientific papers
A new strategy for synthesis of polymeric supports with triazene linkers
Lazny, Ryszard,Nodzewska, Aneta,Klosowski, Piotr
, p. 121 - 130 (2007/10/03)
A new strategy based on the use of diethylamine triazenes for stabilization and generation of polymer supported diazonium ions was described. New economical syntheses of four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were described and compared to the traditional methods. The possible application of the polymer bound triazene masked diazonium salts as supports for immobilization of secondary amines (nortropine and 4-piperidinole and their esterification and oxidation), and as amine scavengers was shown. The new supports with meta-C3-T2 and para-C3-T2 linkers showed higher loadings and typically gave products with good yields and purities.
Synthesis of polymeric supports with spacer-modified triazene linkers: Aldol and Grignard reactions of immobilized nortropinone
Lazny, Ryszard,Nodzewska, Aneta
, p. 2441 - 2444 (2007/10/03)
Four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were synthesized from commercial Merrifield polymer. The supports could be used for immobilization of secondary amines in SPOS. A new strategy based on the use of diethylamine triazenes as masked precursors for the generation of polymer-supported diazonium ions was used. The performance of the new linkers was tested on Grignard and aldol reactions of solid-phase immobilized nortropinone. The new supports with C3-T2 linkers gave products with better yields and purities than the classical T2 supports or the supports with the C6-T2 linkers.
