386743-53-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 308123-42-4 (1R,3aR,4S,7aR)-1-((1S,2R)-2-Hydroxymethyl-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 145223-32-1 2-[(S)-1-((1R,3aR,4S,7aR)-4-Hydroxy-7a-methyl-octahydro-inden-1-yl)-ethyl]-5-methyl-5-triethylsilanyloxy-hexanenitrile 
• 87417-12-7 (3-bromo-1,1-dimethylpropoxy)triethylsilane 
• 93489-60-2 <1R-<1β(R*),3aα,4β,7aβ>>-octahydro-4-hydroxy-β,7a-dimethyl-1H-indene-1-propanenitrile 

Relevant academic research and scientific papers

Stereoselective synthesis of (22R)- and (22S)-22-methyl-1α,25-dihydroxy-vitamin D3

An efficient, straightforward method for construction of the side chain of (22R)- and (22S)-22-alkyl-1α,25-dihydroxyvitamin D3 is described. The title compounds were synthesized by Lythgoe's procedure.

Rapid access to a series of calcitriol analogues with restricted side chain conformation

The synthesis of a series of calcitriol analogues with restricted side chain conformation is described. C-22 modified calcitriol analogues have been prepared from a common intermediate, in which the labile triene system is already present.