386768-84-9

Upstream product

• 626-58-4 4-methylpiperidin 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 386768-81-6 tert-butyl 2-(3-cyanobenzyl)hydrazine-1-carboxylate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 24964-64-5 3-Cyanobenzaldehyde 
• 386768-80-5 N'-[1-(3-Cyano-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 439926-79-1 N'-(3-Cyanobenzyl)-N'-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide 
• 386768-88-3 N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide 
• 439926-99-5 4-methyl-piperidine-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide 

Relevant academic research and scientific papers

Thrombin inhibitors built on an azaphenylalanine scaffold

A series of azaphenylalanine derivatives were investigated as novel thrombin inhibitors based on the prodrug principle. By systematic structural modifications we have identified optimal groups for this series that led us to potent inhibitors of thrombin i

Amidinophenylalanine derivatives as thrombin inhibitors

The compounds of the formula (formula 1) and pharmaceutically acceptable salts thereof and a process for preparing the same and pharmaceutical compositions containing the same are described wherein the substituents have the meaning as specified in the des

Novel thrombin inhibitors with azaphenylalanine scaffold

In this paper the synthesis and antithrombotic activity of a series of novel thrombin inhibitors with azaphenylalanine scaffold are described. By systematic structural modifications for this series we have identified optimal groups for achieving nanomolar potency, that led to potent inhibitors of thrombin with Ki values up to 11 nM.