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Usage

Uses

Used in Pharmaceutical Industry:
5-Methyl-1H-pyrazole-3-carbonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Methyl-1H-pyrazole-3-carbonitrile is employed as a building block for the synthesis of agrochemical products, such as pesticides and herbicides, due to its potential to enhance the effectiveness of these compounds.
Used in Organic Chemistry Research:
5-Methyl-1H-pyrazole-3-carbonitrile is utilized as a reagent in organic chemistry research for its role in facilitating various chemical reactions. Its presence can influence the outcome of syntheses and the formation of desired products in the laboratory.
Used in the Development of New Materials:
Due to its unique chemical structure and reactivity, 5-Methyl-1H-pyrazole-3-carbonitrile has potential applications in the development of innovative materials across different industries, including but not limited to, pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 1117-96-0 Diazoethan 
• 205251-17-8 (Z)-3-[(R)-p-tolylsulfinyl]propenonitrile 
• 4027-56-9 5-methyl-1H-pyrazole-3-carboxylic acid amide 

Relevant academic research and scientific papers

Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a

A series of 5-alkyl pyrazole-3-carboxylic acids were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niacin receptor, GPR109b. A further series of 4-fluoro-5-alkyl pyrazole-3-carboxylic acids were shown to display similar potency. One example from the series was shown to have improved properties in vivo compared to niacin.

(Z)-3-p-tolylsulfinylacrylonitriles as chiral dipolarophiles: Reactions with diazoalkanes

(figure presented) The dipolarophilic reactivity of enantiopure (Z)-3-p-tolylsulfinylacrylonitriles (1) has been evaluated with diazoalkanes. 3-Cyanopyrazoles are obtained when R = H, but with R = alkyl (Bn, n-Bu, and t-Bu) only one cycloadduct (4 or 5) is formed in high yield under mild conditions, therefore evidencing a complete control of the regioselectivity and the endolexo and π-facial selectivities. These reactions are a new straightforward entry to the synthesis of pyrazolines and related structures and reveal the excellent dipolarophilic features of (Z)-sulfinylacrylonitriles.