38693-98-0Relevant academic research and scientific papers
Inhibition of monoamine oxidase by (E)-styrylisatin analogues
Van der Walt, Elizna M.,Milczek, Erika M.,Malan, Sarel F.,Edmondson, Dale E.,Castagnoli Jr., Neal,Bergh, Jacobus J.,Petzer, Jacobus P.
scheme or table, p. 2509 - 2513 (2009/12/31)
Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural reversible inhibitor of both MAO-B
PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS
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Page 26, (2010/11/30)
Racemic or enantiomerically pure 4-pyrrolidino derivatives of the formula (I), processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a mono
N-acylamino benzyl ether derivatives
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, (2008/06/13)
This invention relates to N-acylamino aryl derivatives of the formula 1where R1, R21, R22, R23, R3, R4, R5 R6, R7, R8, R, and n are as defined herein and where X is —CHRO, —OCHR—, —CH2S—, —SCH2—, —CH2CH2—, —CH=CH— or —C≡C—. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
