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Oxydation de la thymidine par l'ozone: comparaison avec l'action des radicaux hydroxyles
Girault, I.,Molko, D.,Cadet, J.
, p. 863 - 870 (2007/10/02)
The reaction of the base moiety of the thymidine, one of the pyrimidinyl nucleosides, with ozone was examined.This reaction gives rise to five nucleosides which were isolated and characterised.The comparison with the current knowledge of the hydroxyl radical-mediated oxidations of thymidine, in aerated aqueous solution, shows that the ozone oxidation is specific.Indeed, the identified products obtained by the ozonolysis resulted from the opening of the C5-C6 bond.
