38709-71-6Relevant academic research and scientific papers
Stereochemical preference of yeast epoxide hydrolase for the O-axial C3 epimers of 1-oxaspiro[2.5]octanes
Weijers, Carel A. G. M.,Koenst, Paul M.,Franssen, Maurice C. R.,Sudhoelter, Ernst J. R.
, p. 3106 - 3114 (2007)
The 1-oxaspiro[2.5]octane moiety is a common motif in many biologically active spiroepoxide compounds. Stereochemistry plays an important role in the action of these spiroepoxides, since the O-axial C3 epimers are predominantly responsible for biological
OXYSTEROLS AND METHODS OF USE THEREOF
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Paragraph 00462, (2018/05/16)
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
Revisiting the Corey-Chaykovsky reaction: The solvent effect and the formation of β-hydroxy methylthioethers
Peng, Yu,Yang, Jin-Hui,Li, Wei-Dong Z.
, p. 1209 - 1215 (2007/10/03)
The classical Corey-Chaykovsky (CC) reaction of ketones in ethereal solvents (i.e., THF or Et2O) resulted in the production of a significant amount of β-hydroxy methylthioether 2 along with normal epoxide product 1. Some interesting and synthet
EPOXIDE FORMATION FROM ALDEHYDES AND KETONES - A MODIFIED METHOD FOR PREPARING THE COREY-CHAYKOVSKY REAGENTS
Ng, John S.
, p. 1193 - 1202 (2007/10/02)
Trimethylsulfoxonium iodide and potassium tert-butoxide in dimethyl sulfoxide (DMSO) is a very efficient process for the multikilogram scale preparation of epoxides from aldehydes and ketones.
