387337-10-2

Basic information

• Product Name: (S)-2-[((S)-2-Benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carbonyl)-amino]-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid methyl ester
• CAS NO: 387337-10-2
• Molecular Weight: 592.713
• Mol File: 387337-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[((S)-2-Benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carbonyl)-amino]-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[((S)-2-Benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carbonyl)-amino]-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid methyl ester(387337-10-2)
• EPA Substance Registry System: (S)-2-[((S)-2-Benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carbonyl)-amino]-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid methyl ester(387337-10-2)

Safety Data

• Hazardous Substances Data: 387337-10-2(Hazardous Substances Data)

Upstream product

• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 
• 887907-92-8 (S)-2-[((S)-2-Benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carbonyl)-amino]-3-(4-bromo-phenyl)-propionic acid methyl ester 
• 99359-33-8 (S)-methyl 2-amino-3-(4-bromophenyl)propanoate 
• 385808-61-7 ethyl 2-azabicyclo[2.2.2]octane-3-carboxylate 
• 387336-55-2 2-benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid 
• 387336-54-1 2-benzenesulfonyl-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester 

Relevant articles and documents

Aza-bicyclic amino acid sulfonamides as α4β 1/α4β7 integrin antagonists

The design, synthesis, and biological activity of novel α 4β1 and α4β7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and known integrin antagonists indicated that this azabicycle would be a suitable molecular scaffold. Variation of substituents on the pendant arylsulfonamide and phenylalanine groups resulted in potent α 4β1-selective and dual α4β 1/α4β7 antagonists. Potent compounds 11i, 11h, and 14 were effective in the antigen-sensitized sheep model of asthma. 2003 Elsevier Science Ltd. All rights reserved.