387343-99-9

Upstream product

• 56341-37-8 6-chloro-2-oxindole 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1015689-14-1 rac-6-chloro-3-(4-chloro-benzyl)-1,3-dihydro-indol-2-one 
• 1015689-16-3 rac-3,5-dibromo-6-chloro-3-(4-chloro-benzyl)-1,3-dihydro-indol-2-one 

Relevant academic research and scientific papers

Asymmetric Synthesis of 3,3′-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators

An enantioselective hetero-Diels-Alder reaction of alkylidene oxindoles and 2-aza-3-silyloxy-1,3-butadienes, catalyzed by divalent transition metal complexes with N, N ′-dioxide ligands offered an efficient access to natural-product-based 3,3′-piperidinoyl spirooxindole class of small molecules. exo -Cycloadducts formed via stereospecific cycloaddition with Z -olefin displayed potent activity in modulation of hedgehog pathway.

OXINDOLE DERIVATIVES

There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.

SPIROINDOLINONE DERIVATIVES

There are provided compounds of the general formulas wherein X, Y, R1, R2, R3 and R4 are as described herein. The compounds exhibit anticancer activity.