387350-79-0

Basic information

• Product Name: N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE
• Synonyms: N-Cyclopropyl-N-(piperidin-4-yl)-3-(trifluoromethyl)benzenesulphonamide
• CAS NO: 387350-79-0
• Molecular Formula: C₁₅H₁₉F₃N₂O₂S
• Molecular Weight: 348.39
• Mol File: 387350-79-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: >195°C
• Boiling Point: 437.9°Cat760mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 7.22E-08mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE(387350-79-0)
• EPA Substance Registry System: N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE(387350-79-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 387350-79-0(Hazardous Substances Data)

Usage

General Description

N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE is a chemical compound that is also known as TAK-242, and it belongs to the family of sulfonamide drugs. It has been studied for its potential anti-inflammatory and immunomodulatory properties, particularly in the field of treating inflammatory and autoimmune diseases. TAK-242 has been shown to inhibit toll-like receptor 4 (TLR4) signaling, which plays a crucial role in the immune response and inflammation. N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE has garnered interest in research for its potential therapeutic applications, although further studies are needed to fully understand its mechanisms of action and potential side effects.

InChI:InChI=1/C15H19F3N2O2S/c16-15(17,18)11-2-1-3-14(10-11)23(21,22)20(12-4-5-12)13-6-8-19-9-7-13/h1-3,10,12-13,19H,4-9H2

Upstream product

• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 179557-01-8 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester 
• 387358-47-6 (1-benzylpiperidin-4-yl)cyclopropylamine 
• 870655-93-9 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide 

Downstream Products

• 953413-71-3 N-(1-acryloyl-piperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide 
• 955033-86-0 C₁₉H₂₃F₃N₂O₅S 
• 953413-74-6 N-cyclopropyl-N-{1-[2-(2-oxo-oxazolidin-3-yl)-benzoyl]-piperidin-4-yl}-3-trifluoromethyl-benzenesulfonamide 

Relevant articles and documents

4-phenylsulfonamidopiperidines as calcium channel blockers

The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS

The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The inve