387350-79-0

Usage

Uses

Used in Pharmaceutical Industry:
N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE is used as a potential therapeutic agent for inflammatory and autoimmune diseases due to its anti-inflammatory and immunomodulatory properties. Its ability to inhibit TLR4 signaling makes it a promising candidate for treating conditions where excessive immune response and inflammation are involved.
Used in Research Applications:
In the field of medical research, N-CYCLOPROPYL-N-PIPERIDIN-4-YL-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE serves as a valuable tool for studying the mechanisms of TLR4 signaling and its role in immune response and inflammation. Further research is necessary to explore its full potential, understand its mechanisms of action, and assess any potential side effects for safe and effective therapeutic use.

InChI:InChI=1/C15H19F3N2O2S/c16-15(17,18)11-2-1-3-14(10-11)23(21,22)20(12-4-5-12)13-6-8-19-9-7-13/h1-3,10,12-13,19H,4-9H2

Upstream product

• 870655-93-9 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide 
• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 179557-01-8 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester 
• 387358-47-6 (1-benzylpiperidin-4-yl)cyclopropylamine 

Downstream Products

• 953413-71-3 N-(1-acryloyl-piperidin-4-yl)-N-cyclopropyl-3-trifluoromethyl-benzenesulfonamide 
• 955033-86-0 C₁₉H₂₃F₃N₂O₅S 
• 1409937-62-7 C₂₂H₂₃F₃N₂O₃S 
• 1409937-63-8 C₂₃H₂₂F₆N₂O₄S 
• 1409937-64-9 C₂₃H₂₂F₆N₂O₄S 
• 1409937-65-0 C₂₃H₂₂F₆N₂O₄S 
• 1409937-66-1 C₂₄H₂₈F₃N₃O₃S 
• 1409937-67-2 C₂₃H₂₄F₃N₃O₄S 

Relevant academic research and scientific papers

4-phenylsulfonamidopiperidines as calcium channel blockers

The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

BENZENESULFONAMIDE COMPOUNDS AND THE USE THEREOF

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth

BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS

The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The inve

SUBSTITUTED PIPERIDINES AS CALCIUM CHANNEL BLOCKERS

Substituted piperidine compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutica