387351-39-5Relevant academic research and scientific papers
Enzyme-Catalyzed Hydrolyses of E/Z-Diastereotopic and E/Z-Diastereomeric Esters. Affect on Selectivity by Reaction Media
Schirmeister, Tanja,Otto, Hans-Hartwig
, p. 4819 - 4822 (1993)
PLE-catalyzed hydrolyses of different types of E/Z-diastereotopic diesters and E/Z-diastereomeric monoesters have been studied.Arylidenepropanedioic diesters are specifically hydrolyzed to the Z-half esters, whereas the de values for dialkylated methylene propanedioic diesters range between 33 and 79percent (Z).D values for the hydrolyses of the 3-methyleneazetidin-2-ones in detergent-buffer systems depend on the size of the substituent in the α-position.Diastereoselectivity of these substrates is affected by addition of the cosolvents acetonitrile and methanol.
β-lactam derivatives as enzyme inhibitors: Derivatives of (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid
Venz,Otto
, p. 686 - 690 (2007/10/03)
The 1,4-diaryl disubstituted azetidin-2-one (β-lactam) 1 is transformed into the 3-methylidene derivative (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid (3), and then, using the DCC/NHS method reacted with amino acid esters and dipeptide esters forming 3-(peptidyl)-β-lactams 5 and 7. Structures and properties are evaluated mainly by spectroscopic methods and discussed. As molecular modeling experiments might suggest a potential activity as inhibitors of PPE(HLE), a number of selected compounds has been tested in an enzyme assay. But none of them showed any remarkable inhibitory activity. Evaluation of the data was done with the new program EnKinPlot.
