387358-53-4 Usage
Uses
Used in Pharmaceutical Industry:
Benzoic acid, 2,3-difluoro-, hydrazide (9CI) is used as a building block for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical industry, Benzoic acid, 2,3-difluoro-, hydrazide (9CI) serves as a key intermediate in the production of various agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, contributing to more sustainable agricultural practices.
Used in Medicinal Chemistry:
Benzoic acid, 2,3-difluoro-, hydrazide (9CI) is utilized in medicinal chemistry for its potential to be incorporated into novel therapeutic agents. Its unique structure and properties may contribute to the development of new drugs with improved efficacy and selectivity, advancing the field of medicine.
While the specific applications and implications of Benzoic acid, 2,3-difluoro-, hydrazide (9CI) are still under investigation, its unique structure and properties suggest a promising future in various industries. Further research and testing are necessary to fully understand and harness its potential.
Check Digit Verification of cas no
The CAS Registry Mumber 387358-53-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,7,3,5 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 387358-53:
(8*3)+(7*8)+(6*7)+(5*3)+(4*5)+(3*8)+(2*5)+(1*3)=194
194 % 10 = 4
So 387358-53-4 is a valid CAS Registry Number.
387358-53-4Relevant academic research and scientific papers
SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents
Del Poeta, Maurizio,Haranahalli, Krupanandan,Lazzarini, Cristina,Mallamo, John,McCarthy, J. Brian,Ojima, Iwao,Pathiranage, Senuri,Sun, Yi,Zambito, Julia
, (2019/09/06)
Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.
