387358-53-4

Basic information

• Product Name: Benzoic acid, 2,3-difluoro-, hydrazide (9CI)
• Synonyms: Benzoic acid, 2,3-difluoro-, hydrazide (9CI);2,3-Difluorobenzoicacidhydrazide98%;2,3-Difluorobenzohydrazide
• CAS NO: 387358-53-4
• Molecular Formula: C₇H₆F₂N₂O
• Molecular Weight: 172.1321464
• Product Categories: HYDRAZIDE
• Mol File: 387358-53-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 2,3-difluoro-, hydrazide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,3-difluoro-, hydrazide (9CI)(387358-53-4)
• EPA Substance Registry System: Benzoic acid, 2,3-difluoro-, hydrazide (9CI)(387358-53-4)

Safety Data

• Hazardous Substances Data: 387358-53-4(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 2,3-difluoro-, hydrazide (9CI) is a chemical compound with the molecular formula C7H5F2N2O. It is a hydrazide derivative of benzoic acid and contains two fluorine atoms attached to the 2 and 3 positions of the benzene ring. Benzoic acid, 2,3-difluoro-, hydrazide (9CI) is primarily used in the pharmaceutical and agrochemical industries for the synthesis of various chemical compounds and as a building block for the production of other organic compounds. It may also have potential applications in the field of medicinal chemistry and drug development due to its unique structure and properties. However, further research and testing are needed to fully understand its potential uses and implications.

Upstream product

• 18355-74-3 methyl 2,3-difluorobenzoate 

Downstream Products

• 886045-83-6 5-(2,3-difluoro-phenyl)-[1,3,4]oxadiazole-2-thiol 

Relevant articles and documents

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.