38746-50-8

Basic information

• Product Name: 2-(4-Methylpyridin-2-yl)acetonitrile
• Synonyms: 2-(4-Methylpyridin-2-yl)acetonitrile;(4-Methyl-pyridin-2-yl)-acetonitrile
• CAS NO: 38746-50-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.17
• Mol File: 38746-50-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 255.481°C at 760 mmHg
• Flash Point: 98.436°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: 2-8°C
• PKA: 3.84±0.20(Predicted)
• CAS DataBase Reference: 2-(4-Methylpyridin-2-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylpyridin-2-yl)acetonitrile(38746-50-8)
• EPA Substance Registry System: 2-(4-Methylpyridin-2-yl)acetonitrile(38746-50-8)

Safety Data

• Hazardous Substances Data: 38746-50-8(Hazardous Substances Data)

Usage

General Description

2-(4-Methylpyridin-2-yl)acetonitrile, also known as 4-methyl-2-(pyridin-2-yl)acetonitrile or 4-Methyl-2-pyridin-2-ylacetonitrile, is a chemical compound with the molecular formula C9H9N. It is a nitrile derivative of 4-methyl-2-pyridin-2-ylacetic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-(4-Methylpyridin-2-yl)acetonitrile is a white to light yellow solid, with a melting point of 54-56 °C, and is soluble in organic solvents such as ethanol and ethyl acetate. 2-(4-Methylpyridin-2-yl)acetonitrile is primarily used in the manufacturing of various drugs and compounds, and its unique chemical structure makes it a valuable building block in organic synthesis.

InChI:InChI=1/C8H8N2/c1-7-3-5-10-8(6-7)2-4-9/h3,5-6H,2H2,1H3

Upstream product

• 1003-67-4 4-methylpyridine-1-oxide 
• 38198-16-2 4-methyl-pyridin-2-ylmethyl chloride 

Downstream Products

• 187592-35-4 2-(o-Chlorophenyl)-3-oxo-4-(4-methylpyridyl)-5-amino-2,3-dihydrofurane 

Relevant articles and documents

Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Flash Vacuum Pyrolysis of Substituted Pyridine N-Oxides and Its Application to Syntheses of Heterocyclic Compounds

Flash vacuum pyrolysis of 2-picoline N-oxide gave 2-picoline, pyridine, 2-ethylpyridine, 2-vinylpyridine, 2-pyridylmethanol, bis(2-pyridyl)methane, 1,2-bis(2-pyridyl)ethane, and 1,2-bis(2-pyridyl)ethylene.These reactions are explained by intermediary participation of the 2-picolyl radical.Flash vacuum pyrolysis of methyl-substituted 2-benzylpyridine N-oxides led to methyl-substituted pyridoindoles or to benzoquinoline in moderate yields.