38747-55-6Relevant academic research and scientific papers
Preparation of pyrimidin-2-one derivatives via base-mediated decomposition of uracil-analogues Fischer carbene complex
Bocchino, Carmen,Carabellese, Antonella,Caruso, Tonino,Della Sala, Giorgio,Ricart, Susagna,Spinella, Aldo
, p. 47 - 50 (2013/10/22)
A practical and efficient synthesis of pyrimidin-2-one derivatives from Fischer carbene complex uracil-analogues through base-mediated elimination reactions is described. The scope of the protocol has been explored with the preparation of a variety of pyrimidin-2-one derivatives by base mediated demetallation of N-1 and N-3 substituted uracil Fischer carbenes.
Synthesis of uracil derivatives by oxidation of Fischer tungsten-carbene uracil complexes
Sala, Giorgio Della,Artillo, Antonietta,Ricart, Susagna,Spinella, Aldo
, p. 1623 - 1627 (2007/10/03)
A study on the oxidation of Fischer tungsten-carbene uracil complexes has been carried out. Several commonly used oxidants gave results strongly influenced by the presence of substituent on nitrogen atoms. In particular, usual oxidants failed in the oxidation of 3-alkyl uracil carbene complexes. Finally, we showed that t-butyl hydroperoxide is able to oxidize successfully also 3-alkyl uracil carbene complexes and can be used as a good alternative to the other methods.
