38749-76-7

Basic information

• Product Name: Pyridine, 3-bromo-4-ethyl- (9CI)
• Synonyms: Pyridine, 3-bromo-4-ethyl- (9CI);3-Bromo-4-ethyl-pyridine ;4-Ethyl-3-bromopyridine
• CAS NO: 38749-76-7
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.04912
• Product Categories: PYRIDINE
• Mol File: 38749-76-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 216.7 °C at 760 mmHg
• Flash Point: 84.8 °C
• Appearance: /
• Density: 1.413 g/cm³
• Vapor Pressure: 0.203mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.68±0.18(Predicted)
• CAS DataBase Reference: Pyridine, 3-bromo-4-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-bromo-4-ethyl- (9CI)(38749-76-7)
• EPA Substance Registry System: Pyridine, 3-bromo-4-ethyl- (9CI)(38749-76-7)

Safety Data

• Hazardous Substances Data: 38749-76-7(Hazardous Substances Data)

Usage

General Description

Pyridine, 3-bromo-4-ethyl- (9CI) is an organic compound with the chemical formula C7H8BrN. It belongs to the class of pyridine derivatives, which are widely used in pharmaceuticals and agrochemicals. This specific compound, 3-bromo-4-ethyl-pyridine, is a brominated derivative of pyridine with an ethyl group attached to the fourth carbon atom. It is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle this chemical with caution, as it is flammable and may cause irritation to the skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C7H8BrN/c1-2-6-3-4-9-5-7(6)8/h3-5H,2H2,1H3

Upstream product

• 626-55-1 3-Bromopyridine 
• 536-75-4 4-Ethylpyridine 

Downstream Products

• 2096330-85-5 4-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant articles and documents

6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, Q, R3, R4, R5, R6, A1, and A2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

SYNTHESIS OF 3-HALO- AND 3-FORMYL-4-ALKYLPYRIDINES

In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-halopyridines gives 4-alkyl-3-halo-1-phenoxycarbonyl-1,4-dihydropyridines.The crude dihydropyridines were aromatized with o-chloroanil to give 4-alkyl-3-halopyridines.Several 4-alkylnicotinaldehydes were synthesized in a similar manner from the cyclic acetal (1,3-dioxolane) of 3-pyridinecarboxaldehyde.After aromatization with sulfur, the crude acetals were hydrolyzed with oxalic acid to give the desired pyridinecarboxaldehydes.