38752-48-6Relevant academic research and scientific papers
Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow
Audubert, Clément,Bouchard, Alexanne,Mathieu, Gary,Lebel, Hélène
, p. 14203 - 14209 (2019/01/21)
The chemoselective amination of alkyl bromides and chlorides with aqueous ammonia and hydroxylamine was achieved in continuous flow to produce primary ammonium salts and hydroxylamines in high yields. An in-line workup was designed to isolate the corresponding primary amine, which was also telescoped in further reactions, such as acylation and Paal-Knorr pyrrole synthesis. Monosubstituted epoxides are also compatible with the reaction conditions.
Anilinoquinazolines as protein tyrosine kinase inhibitors
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Page/Page column 77, (2008/06/13)
Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
Anilinoquinazaolines as protein tyrosine kianse inhibitors
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Page/Page column 48, (2008/06/13)
Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
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, (2008/06/13)
The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this inv
N-(arylthioalkyl)-N'-(aminoalkyl)ureas
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, (2008/06/13)
N-(arylthioalkyl)-N'-(aminoalkyl)ureas and thioureas and oxidation derivatives having the formula STR1 wherein B is thio, sulfinyl or sulfonyl; R1 and R2 are hydrogen, loweralkyl, cycloalkyl, 2-furanyl, phenyl, substituted phenyl or phenyl-loweralkyl and R3 and R4 are hydrogen, loweralkyl, phenyl or phenyl-loweralkyl wherein phenyl is optionally substituted, or R3 and R4 taken with the adjacent nitrogen form a heterocyclic residue.
