38753-78-5 Usage
Uses
Used in Pharmaceutical Industry:
Discodermolide is used as a microtubule-stabilizing agent for its potential as an anti-cancer drug candidate. Its ability to stabilize microtubules contributes to the inhibition of cell division and the prevention of cancer cell proliferation, making it a promising compound for the development of cancer treatments.
Used in Chemical Synthesis:
Discodermolide's unique and complex chemical structure makes it an interesting target for chemical synthesis. Researchers aim to develop efficient and scalable synthetic routes to produce (2'R,10R,13S)-10,13-DIMETHYL-1,7,8,9,10,11,12,13,15,16-DECAHYDRO-3'H-SPIRO[CYCLOPENTA[A]PHENANTHRENE-17,2'-FURAN]-3,5',6(2H,4'H,14H)-TRIONE, facilitating its use in pharmaceutical applications and further exploration of its potential therapeutic properties.
Used in Pharmaceutical Research:
The biological activity and structural complexity of Discodermolide make it a valuable subject for pharmaceutical research. Scientists are investigating its mechanism of action, potential side effects, and ways to improve its efficacy and safety as a potential anti-cancer agent.
Check Digit Verification of cas no
The CAS Registry Mumber 38753-78-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,7,5 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 38753-78:
(7*3)+(6*8)+(5*7)+(4*5)+(3*3)+(2*7)+(1*8)=155
155 % 10 = 5
So 38753-78-5 is a valid CAS Registry Number.
38753-78-5Relevant academic research and scientific papers
Isolation and identification of novel sulfur-containing metabolites of spironolactone (Aldactone)
Karim, Aziz,Brown, Edward A.
, p. 41 - 62 (2007/10/10)
In the urine of subjects given an oral dose of spironolactone [3-(3-oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-y1)propionic acid γ-lactone], six metabolites have been detected. One of the major metabolites was found to be the previously characterized de-thioacetylated compound, 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-y1)propionic acid γ-lactone (canrenone). Besides this a new major sulfur-containing metabolite has been isolated and identified as 3-(3-oxo-7α-methylsulfinyl-6β,17β-dihydroxy-4-androsten-17α-y1)propionic acid γ-lactone. This structural assignment was based on detailed analysis of its IR, NMR and UV spectra as well as comparison of its physical constants and chromatographic (TLC and GLC) characteristics with a synthetic sample. The three minor metabolites were found to be very labile and were readily converted to canrenone.
