3877-86-9Relevant academic research and scientific papers
Cucurbitacin derivatives and preparation method thereof
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Paragraph 0125, (2018/04/21)
The invention discloses multiple new derivatives of cucurbitacin-B and cucurbitacin-E and salts of the new derivatives, and also discloses a preparation method of the new derivatives. As the new derivatives and the salts thereof have the same basic structures as cucurbitacin-B and cucurbitacin-E respectively, the nature of the new derivatives and the salts thereof is basically the same as that ofcucurbitacin-B and cucurbitacin-E, and the new derivatives and the salts thereof have good anti-cancer, anti-virus, anti-inflammation and liver protection effects with low toxic and side effects.
New Cytotoxic Principles from Datisca glomerata
Sasamori, Hiroshi,Reddy, K. Sambi,Kirkup, Michael P.,Shabanowitz, Jeffrey,Lynn, David G.,at al.
, p. 1333 - 1347 (2007/10/02)
Datisca glomerata has been systematically fractionated by following cellular toxicity in an effort to identify previously uncharacterized cytotoxic principles.Several new cucurbitacin glycosides, including datiscosides B(8), C(3), D(9), E(4), F(5), G(6), and H(10) and the known compound datiscoside (1), as well as cucurbitacins B(11), D(2), and F(7) have been isolated and characterized.Structures were assigned to the compounds on the basis of their high field 1H n.m.r., 13C n.m.r., high-resolution mass spectra (CI, EI, and FD) and chemical interconversions.The structure of datiscoside C(3) was independently established by single-crystal X-ray analysis at 193 and 293 K.
