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Muristerone A is a natural analog of 20-hydroxyecdysone and functions as an agonist of the ecdysteroid receptor, which plays a crucial role in regulating arthropod development. It is characterized by its ability to heterodimerize with a retinoid X receptor ortholog and is used in ecdysone-inducible gene expression systems in mammalian cells. However, its inhibition of apoptosis in human colon carcinoma cell line RKO by upregulating Bcl-xL indicates potential limitations in specific research applications.

38778-30-2

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38778-30-2 Usage

Uses

Used in Pharmaceutical Research:
Muristerone A is utilized as an agonist in ecdysone-inducible gene expression systems in mammalian cells, aiding in the study of ecdysteroid receptor functions and its role in various biological processes.
Used in Cell Biology Studies:
Due to its ability to inhibit apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, Muristerone A serves as a valuable tool in understanding cell survival mechanisms and apoptosis regulation in cancer research. However, its limitations in certain types of studies should be taken into consideration.

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

Check Digit Verification of cas no

The CAS Registry Mumber 38778-30-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,7,7 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38778-30:
(7*3)+(6*8)+(5*7)+(4*7)+(3*8)+(2*3)+(1*0)=162
162 % 10 = 2
So 38778-30-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H44O8/c1-14(2)6-7-20(31)25(5,33)19-8-9-26(34)15-10-21(32)27(35)13-17(29)16(28)11-24(27,4)22(15)18(30)12-23(19,26)3/h10,14,16-20,22,28-31,33-35H,6-9,11-13H2,1-5H3/t16-,17+,18+,19-,20+,22+,23+,24+,25+,26+,27+/m0/s1

38778-30-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R,5S,9R,10R,11R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,5,11,14-pentahydroxy-10,13-dimethyl-1,2,3,4,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-6-one

1.2 Other means of identification

Product number -
Other names Muristerone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38778-30-2 SDS

38778-30-2Upstream product

38778-30-2Downstream Products

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