387826-55-3

Basic information

• Product Name: Propanamide, N-[3-[1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-piperidinyl] phenyl]-2-methyl-
• CAS NO: 387826-55-3
• Molecular Formula: C26H31N3O3
• Molecular Weight: 433.55
• Mol File: 387826-55-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Propanamide, N-[3-[1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-piperidinyl] phenyl]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-[3-[1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-piperidinyl] phenyl]-2-methyl-(387826-55-3)
• EPA Substance Registry System: Propanamide, N-[3-[1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-4-piperidinyl] phenyl]-2-methyl-(387826-55-3)

Safety Data

• Hazardous Substances Data: 387826-55-3(Hazardous Substances Data)

Upstream product

• 387827-32-9 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 79-30-1 isobutyryl chloride 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 626-01-7 3-Iodoaniline 
• 387827-31-8 4-(3-isobutyrylaminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 387827-30-7 4-[3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylic acid tert-butyl ester 
• 430464-44-1 N-(3-iodophenyl)isobutyramide 

Downstream Products

• 486449-00-7 N-{3-[1-(3-aminopropyl)piperidin-4-yl]phenyl}isobutyramide 

Relevant articles and documents

Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.

DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention further provides a method of treating a subject suffering from urinary incontinence which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's urinary incontinence.