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(E,E,E)-geranylgeranylacetone, also known as GGA, is a diterpenoid compound with the chemical formula C25H40O. It is a synthetic derivative of acetylacetone and is recognized for its potential therapeutic properties, including the protection against stress-induced cell damage. GGA has been investigated for its roles in cancer treatment and the prevention of neurodegenerative diseases, as well as for its anti-inflammatory and antioxidant capabilities, positioning it as a significant compound in medicinal chemistry.

3879-23-0

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3879-23-0 Usage

Uses

Used in Pharmaceutical Research:
(E,E,E)-geranylgeranylacetone is used as a chemical inducer for heat shock proteins, which are crucial for cellular protection and repair mechanisms. Its application aids in understanding the mechanisms of cellular stress response and the potential for developing therapeutic strategies against various diseases.
Used in Cancer Treatment:
(E,E,E)-geranylgeranylacetone is used as a potential therapeutic agent in cancer treatment. It has been studied for its ability to protect against stress-induced cell damage, which could be beneficial in the context of cancer cells that often experience high levels of stress.
Used in Neurodegenerative Disease Prevention:
(E,E,E)-geranylgeranylacetone is used as a preventative agent against neurodegenerative diseases due to its potential protective effects on neuronal cells from stress-induced damage.
Used in Medicinal Chemistry:
(E,E,E)-geranylgeranylacetone is used as a subject of interest in medicinal chemistry for its anti-inflammatory and antioxidant properties, which could contribute to the development of new drugs targeting inflammation and oxidative stress-related conditions.
Used in Research and Development:
(E,E,E)-geranylgeranylacetone is used as a research compound to explore its potential applications in various fields, including its protective effects against cell damage, its role in the treatment of cancer and neurodegenerative diseases, and its general utility in the study of cellular stress responses.

Check Digit Verification of cas no

The CAS Registry Mumber 3879-23-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,7 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3879-23:
(6*3)+(5*8)+(4*7)+(3*9)+(2*2)+(1*3)=120
120 % 10 = 0
So 3879-23-0 is a valid CAS Registry Number.

3879-23-0Relevant academic research and scientific papers

Superacidic low-temperature cyclization of terpenols and their acetates

Vlad, P. F.,Ungur, N. D.,Nguen Van Hung,Perutsky, V. B.

, p. 2391 - 2403 (2007/10/03)

The superacidic low-temperature cyclization of terpenols and their acetates be fluorosulfonic acid represents a highly efficient chemo- and structurally selective and stereospecific process.Homoallylic alcohols (α-isomers of cycloterpenols) are the products of cyclization of terpenols; the configuration of the hydroxymethyl group in the products is predetermined by the configuration of the allylic double bond in aliphatic or partially cyclized precursors.The cyclization of terpenyl acetates yields monoacetates of fully cyclized diastereomeric primary-tertiary γ-diols.Their stereochemistry also depends on the configuration of the allylic double bond in the starting substrates. - Key words: terpenols; terpenyl acetates; cyclization, fluorosulfonic acid, drimanes, isoagathanes, scarlanes.

Structure and Biosynthesis of Cleomeprenols from the Leaves of Cleome spinosa

Suga, Takayuki,Shishibori, Tsuyoshi

, p. 2098 - 2104 (2007/10/02)

Cleomeprenols isolated from Cleome spinosa L. (Capparidaceae) have been identified as nonaprenol (1), decaprenol (2), and undecaprenol (3), which are composed of an ω-terminal isoprene, three internal E-isoprene, and the remaining Z-isoprene residues, respectively.Feeding experiments using stereospecifically double-labelled radioactive mevalonate showed that all the cleomeprenols are composed of four biogenetically E- and the remaining biogenetically Z-isoprene residues.Occurence of the succesive cis-condensation of isoprene residues with (2E,6E,10E)-geranylgeranyl pyrophosphate was demonstrated by comparing the incorporation of a homologue of all-E-prenyl pyrophosphates with that of the corresponding 2Z-isomer.

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