388074-08-6Relevant academic research and scientific papers
Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation
Ghosh, Arun K.,Kumaragurubaran, Nagaswamy,Hong, Lin,Kulkarni, Sarang,Xu, Xiaoming,Miller, Heather B.,Srinivasa Reddy, Dandepally,Weerasena, Vajira,Turner, Robert,Chang, Wanpin,Koelsch, Gerald,Tang, Jordan
, p. 1031 - 1036 (2008/09/20)
Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic β-secretase inhibitors incorporating hydroxyethylamine isosteres are described. We have identified inhibitor 24 which has shown exceedingly potent activity in memap
