388118-60-3

Upstream product

• 70197-13-6 methyltrioxorhenium(VII) 
• 388118-59-0 4-(4-fluoro-3-trifluoromethyl-phenyl)-pyridine 
• 1692-15-5 4-pyridylboronic acid 
• 393-37-3 5-bromo-2-fluorobenzotrifluoride 

Downstream Products

• 388118-65-8 4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine 1-oxide 

Relevant academic research and scientific papers

Amino-substituted heterocycles as isosteres of trans-cinnamides: Design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

2-Amino-4-phenyl pyridine and, to a lesser extent, 4-amino-6-phenyl pyrimidine, were established as isosteres of trans-cinnamide moiety. Applying this isosterism to previously reported p-arylthio cinnamides resulted in the identification of 4-amino-6-(p-arylthio)phenyl-pyrimidines and 2-amino-4-(p-arylthio)phenyl-pyridines as potent antagonists of LFA-1/ICAM-1 binding.

Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents

The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.