38817-30-0Relevant academic research and scientific papers
Fluorinase-coupled base swaps: Synthesis of [18F]-5′- deoxy-5′-fluorouridines
Winkler, Margit,Domarkas, Juozas,Schweiger, Lutz F.,O'Hagan, David
supporting information; experimental part, p. 10141 - 10143 (2009/05/30)
(Chemical Equation Presented) Making F-ases: One-pot fluorination/base-swap biotransformations were developed by coupling the fluorinase enzyme to nucleoside phosphorylases to generate 5′-deoxy-5′-fluoronucleosides (FDAs). These biotransformations are amenable to radiolabeling syntheses starting from [18F]fluoride ion, as exemplified by the synthesis of [18F]-5′-deoxy-5′-fluorouridines (see scheme), and demonstrate a new application of fluorinase as a catalyst for 18F-C bond formation.
